Bruce E. Maryanoff, Cynthia A. Maryanoff, "Advances in Medicinal Chemistry, Volume 3"
Publisher: Jai Pr | 1995-12-01 | 187 Pages | ISBN: 155938798X | PDF | 10 MB
Publisher: Jai Pr | 1995-12-01 | 187 Pages | ISBN: 155938798X | PDF | 10 MB
Hardbound. Volume 3 of Advances in Medicinal Chemistry is comprised of four chapters on diverse aspects of medicinal chemistry. Chapter 1 presents an account of a research program which was started to discover a novel antipsychotic agent with minimal side effects for the treatment, principally, of schizophrenia. Chapter 2 relates an account on the discovery of novel antithrombotic drugs based on the RGD motif through a rational design approach. Chapter 3 presents themedicinal chemistry and preclinical development surrounding sertraline, a very important serotonin reuptake drug for the treatment of endogenous depression. Finally, Chapter 4 gives a summary of a series of boronic acid-based immunosuppressants that operate via inhibition of dipeptidypeptidase IV..
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